AXON works by connecting the TEM, imaging detectors and holder systems together creating the first product utilizing machine vision technology to stabilize images for traditional and in situ electron microscopy. There is no such thing as a “perfect” TEM holder, but we knew through software, we could essentially make one. Most importantly, however, we believe the value we create is in the data our users collect. The higher the quality and the better it's organized, the more impactful your results will be. We’re looking to fundamentally change everything.

Our goal in creating AXON was three-fold: 1) Increase the performance of the TEM and ancillary instruments, 2) Improve the productivity of research, and 3) Make the process of discovery far faster and easier.

Creating connections in the lab to enable unprecedented performance.

Utilizing Machine Vision and AI technologies to enhance discoveries.

Bridging the nano and macro-scale worlds.

brain connectors


One major reason for analyzing materials in the TEM is resolution, however, instabilities introduced by the technique can quickly limit the achievable resolution in the instrument. Using machine vision technology and constantly analyzing the images coming from the cameras or detectors, AXON can quickly determine if anything has changed in position and make adjustments to the beam or stage. This is done many times a second, much faster than a person can, and the end result is an extremely stable image regardless of the instabilities caused by the experiment. Most importantly, high resolution is achievable under nearly any situation.



Many TEM users today aren’t experts in microscopy and need the support of local staff to run experiments. This can be a burden for laboratory facilities and a barrier for the chemists, physicists and engineers who only occasionally use these instruments. AXON can act as a separate pair of hands, allowing the user to focus on the science of the sample rather than the operation of the instrument. In addition, with new tools like AXON Studio™, users can utilize the vast amount of synchronized metadata to organize and review thousands of images at once, at your desk and on your laptop and more easily create datasets shareable with collaborators.

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Identifying critical data in a TEM experiment can be like finding a needle in a haystack. AXON’s Studio’s analysis tools help the user make previously unseen correlations to quickly identify trends, locate the most important regions and export data for further analysis. Since AXON is a machine vision and artificial intelligence platform that connects many instruments in the TEM lab, correlations can be made between detectors and even downstream in situ tools that record information about the sample’s environment and synchronize the metadata within every image in real time. In addition, AXON helps to identify and tag data for deletion that is repetitive, allowing the user to greatly reduce the size of the haystack and ensure only the important data is archived.

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We designed AXON with a modular architecture. Our first module is called Synchronicity, and it's the foundation for the product. This is the module that provides drift correction, focus, and data synchronization. With the newly released AXON Studio™, data is quickly and easily analyzed outside of the lab with a powerful indexing engine capable of handling thousands of images at once. Going forward, Protochips has a full R&D pipeline for new features and new modules that will impact many different applications. We’re certainly excited for the next few years and this is just the beginning.

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Learn more about the capabilities, functionality, and construction about this product including specifications, certifications, and the variations we offer.


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